ペプチド合成受託、タンパク質・ペプチドを中心とした研究開発・調査。実験器具類や試薬、バイオチップの販売

原著論文・共著本

原著論文

2017年

  • バイオチップの基礎と応用―原理から最新の研究・開発動向まで―伊藤嘉浩監修  (単行本・共著)
    5.糖ペプチドマイクロアレイ 軒原清史 pp 103-113. シーエムシー出版
    Biochip Technologies -Principle and Applications- CMC Publishers 2015
  • Nokihara, K., Kasama, T., Tominaga, Y, Kitagawa, A. and Hirata, A. Peptide Science 2016: K. Akaji (Ed.) The Japanese Peptide Society, pp 33-34, 2017. Routine deconvolution method for a cyclic peptide immobilized on a gel-type single bead (OPOB) without Edman-degradation
  • Tominaga, Y., Usui, K., Hirata, A., Kitagawa, A., Ito, H. and Nokihara, K. Peptide Science 2016: K. Akaji (Ed.) The Japanese Peptide Society, pp 131-132, 2017. Development of Peptide Microarray to Detect the Protein in Saliva for Periodontal Disease Test.
  • 軒原清史 医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―平野義明監修 (単行本・共著) 第Ⅶ編 診断・イメージング 第7編 第5章 ペプチドマイクロアレイPepTenChip®システムによる検査診断pp 306-315. シーエムシー出版
  • 軒原清史他 ペプチド医薬品開発のスクリーニング・安定化・製剤化技術 (単行本・共著) 第1章ペプチドライブラリーの構築とスクリーニング技術 10節 ペプチドビーズライブラリーを用いた標的探索:著者 軒原清史、笠間健嗣、平田晃義、冨永祐希、北川篤、軒原駿 in press http://www.gijutu.co.jp, 技術情報協会
  • 投稿論文

    Tominaga, Y., Usui, K., Hirata1, A., Ito, H., and Nokihara, K., Applications of a novel biodetection system to saliva using protein fingerprints with data processing

    2016年

  • Wang, N., Hirata, A., Nokihara, K., Fukase, K., Fujimoto, Y. Biopolymers 106, 422-429, 2016.
    Peptidoglycan microarray as a novel tool to explore protein-ligand recognition
  • Sasaki, A., Ide, S., Kawamoto, Y., Bando, T, Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K.
    Sciemtific Reports, DOI:10.1038/srep29261 www.nature.com/scientificreports
    Telomere visualization in Tissue sections Using the Pyrrole-Imidazole Polyamide probes
  • Nokihara, K., Kasama, T., Tominaga, Y., Kitagawa, A., Hirata, A., Ohyama, T. and Yazawa, I., Amino Acids, online 08 June 2016, Doi:10.1007/s00726-016-2269-1, 2016 Nov; 48(11): 2491-2499.
    High throughput sequencing of cyclic peptide immobilized on a gel-type single bead
  • Ohashi, Y., Ohnuma, R., Naganuma, T., Ogawa, T., Naude, R., Nokihara, K. and Muramoto, K. Food Science and Technology Research, 21 (5), 695-704, 2015.
    Antioxidant Properties of Tripeptides Revealed by a Comparison of Six Different Assays
  • Nokihara, K., Tominaga, Kitagawa, A., Hirata, A. and Kasama, T. Peptide Science 2015, H. Hojo, T. Inazu, H. Katayama (eds.) The Japanese Peptide Society, pp 69-72, 2016.
    High throughput amino acid analysis and sequence determination by a novel system without any derivatization using a novel column and mass spectrometer
  • 2015年

  • Nokihara,K., Hirata, A., Tominaga, Y., Kitagawa, A., Kasama, T. Peptide Science 2014, A. Ohtaka (ed.) The Japanese Peptide Society(2015), 51-54,Chemical Syntheses with QC-methods of Peptides Consisting of N-methyl pyrrole and N-methyl imidazole Residues and Elucidation of their Microheterogeneity
  • Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Maeshima, K., Sasaki, A., Ide, S., Sugiyama, H. Peptide Science 2014, A. Ohtaka (ed.) The Japanese Peptide Society(2015), 73-74.
    Synthesis and characterization of tandem hairpin polyamide for telomeres visualization
  • Tominaga, Y., Hirata, A., and Nokihara, K., Bioorg. Med. Chem. Lett. 25, 611–615, 2015.
    Recognition of a monoclonal antibody against a small molecular weight antigen by monitoring the antigen–antibody reaction using fluorescence labeled structured peptides
  • 2014年

  • Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Sasaki, A., Ide, S., Maeshima, K., Kasama, T., Sugiyama, H. J. Am. Chem. Soc. 136, 11546-11554, 2014.
    Structural evaluation of tandem hairpin pyrrole-imidazole polyamides recognizing human telomeres
  • Hirata, A., Nokihara, K., Tetrahedron Lett. 55, 4091-4094, 2014.
    Construction of peptide-vehicles, bioconjugates having modules of cancer cell surface capture and cell-penetrating peptide with anticancer agents, focusing on efficient drug delivery
  • Nokihara, K. Yajima, Y., Hirata, A., Prion, 8, 1-2, 2014.
    Design and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP (mini review)
  • Nokihara, K. Tominaga, Y. Ueta G. Hirata, A., Peptide Science 2013, Y. Nishiuchi and T. Teshima (Eds.) The Japanese Peptide Society (2014) pp 389-392.
    Recognition studies focusing on a novel bio-detection system using arrays consisting of fluorescent labeled structured peptides as capture molecules
  • Hirata, A., Miyajima, M., Tominaga, Y. Ueta G. Nokihara, K. Peptide Science 2013, Y. Nishiuchi and T. Teshima (Eds.) The Japanese Peptide Society (2014) pp 145-148.
    Comparison of Recently Developed Polymer Supports for Assembly of Structured Polyamide in Solid-phase Syntheses
  • 2013年

  • Hirata, A., Miyajima, M., Nokihara, K., J. Liq. Chromatogr. Relat. Technol., 36, 2960- 2967, 2013.
    Separation of peptides having structures and derivatives of mimosine, a nonproteinogenic amino acid, by a novel reverse- phase HPLC column packed with wide-pore silica
  • Nokihara, K., Yajima, S., Hirata, A., Sogon, T., Yasuhara, T., FEBS Lett., 587, 673-676, 2013. Characterization of peptides obtained from digests of bovine brain which accelerate structural conversions of the recombinant bovine prion protein
  • Mihara, H., Usui, K., Tsutsumi, H. and Nokihara, K., Peptides, Peptides Across the Pacific, pp22-23, 2013, M. Label (Ed), Proceedings of the 23rd American Peptide Symposium
    Designed Peptide Libraries for Cell Analyzing Microarrays
  • Nokihara, K., Pipkorn, R., Ohyama, T., Hirata, A., Miyajima, M., Ono, N., Peptide Science 2012: K. Sugimura (Ed) The Japanese Peptide Society, pp 167-170, 2013.
    Improved Coupling Methods for the Difficult Amide-Bond Formation in Solid-Phase Assembly
  • 2012年以前の原著論文

    2000~2012年

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