原著論文
2023
- Sasaki, T., Kasama, T. and Nokihara, K. (2023). A novel cyclic peptide library immobilized on gel-type beads focusing on rapid construction and characterization for comprehensive drug discovery. Chemical Biology & Drug Design, 102, 1327-1335, 2023. DOI https://doi.org/10.1111/cbdd.14331
- Tominaga, Y. and Nokihara, K., International Journal of Peptide Research and Therapeutics, 28, 95-98, 2022. DOI 10.1007/s10989-022-10404-2.
タイトル Investigation of the Behaviors of Molecules Exhibiting Angiogenic Actions
Tominaga, Y., Kitagawa, A., Sasaki, T., Kasama, T and Nokihara, K., Peptide Science 2022; T. Doi, H. Konno (Eds.) The Japanese Peptide Society, pp 47-48, 2023.
タイトル Design, syntheses and endogenous behavior of novel angiogenic peptides for clinical applications - Nokihara, K., Sasaki, T., Kasama, T. Kitagawa, A. and Tominaga, Y. , Peptide Science 2022; T. Doi, H. Konno (Eds.) The Japanese Peptide Society, pp 59-60, 2023.
タイトル Production and high-throughput deconvolution of OPOB-libraries towards comprehensive discovery of medicinal middle molecules
2022
- Recent publication in “International Journal of Peptide Research and Therapeutics“
on line 2022 April 22, DOI 10.1007/s10989-022-10404-2.
Investigation of the Behaviors of Molecules Exhibiting Angiogenic Actions
Authors: Tominaga, Y. and Nokihara, K.,
Article is related to engraftment in regenerative medicine and clarified the molecular behavior that novel cyclic AGP molecules contribute to the tubular formation of in human umbilical vein endothelial cells directly without degradation.
2021
- Peptide Science 2020, Matsuura, K., and Kawano, T. (Eds) pp43-46, 2021.
Authors: Nokihara, K., Tominaga, Y., Kasama, T., Fujino, H., Kitagawa, A., Sasaki, T. and Nokihara, S.,
Construction of the higher efficient systems, a novel larger scale-personal synthesizer, PSP-5200, and rapid characterization for large number of peptide libraries
Article is related to applications of a newly released personal synthesizer PSP-5200
2020
- Recent publication in “Bioorganic & Medicinal Chemistry, 28 (2020) 115685,
on line 2020 Aug 3, DOI:10.1016/j.bmc.2020.115685“
Improved design of peptides exhibiting angiogenic activities for clinical
applications
Authors: Tominaga, Y., Kitagawa, A. and Nokihara, K.,
Article is related to engraftment in regenerative medicine and several new
peptide derivatives exhibited to enzymatic resistance were developed for
clinical applications.
2017年
- バイオチップの基礎と応用―原理から最新の研究・開発動向まで―伊藤嘉浩監修 (単行本・共著)
５．糖ペプチドマイクロアレイ 軒原清史 pp 103-113. シーエムシー出版
Biochip Technologies -Principle and Applications- CMC Publishers 2015 - Nokihara, K., Kasama, T., Tominaga, Y, Kitagawa, A. and Hirata, A. Peptide Science 2016: K. Akaji (Ed.) The Japanese Peptide Society, pp 33-34, 2017. Routine deconvolution method for a cyclic peptide immobilized on a gel-type single bead (OPOB) without Edman-degradation
- Tominaga, Y., Usui, K., Hirata, A., Kitagawa, A., Ito, H. and Nokihara, K. Peptide Science 2016: K. Akaji (Ed.) The Japanese Peptide Society, pp 131-132, 2017. Development of Peptide Microarray to Detect the Protein in Saliva for Periodontal Disease Test.
- 軒原清史 医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―平野義明監修 (単行本・共著) 第Ⅶ編 診断・イメージング 第7編 第5章 ペプチドマイクロアレイPepTenChip®システムによる検査診断pp 306-315. シーエムシー出版
- 軒原清史他 ペプチド医薬品開発のスクリーニング・安定化・製剤化技術 (単行本・共著) 第1章ペプチドライブラリーの構築とスクリーニング技術 10節 ペプチドビーズライブラリーを用いた標的探索：著者 軒原清史、笠間健嗣、平田晃義、冨永祐希、北川篤、軒原駿 in press http://www.gijutu.co.jp, 技術情報協会
- Tominaga, Y., Usui, K., Hirata, A., Ito, H. and Nokihara, K., Bioorganic &
Medicinal Chemistry, in press, https://doi.org/10.1016/j.bmc.2018.04.049,Applications of a novel biodetection system to saliva using protein
fingerprints with data processing
2016年
- Wang, N., Hirata, A., Nokihara, K., Fukase, K., Fujimoto, Y. Biopolymers 106, 422-429, 2016.
Peptidoglycan microarray as a novel tool to explore protein-ligand recognition - Sasaki, A., Ide, S., Kawamoto, Y., Bando, T, Murata, Y., Shimura, M., Yamada, K., Hirata, A., Nokihara, K., Hirata, T., Sugiyama, H., Maeshima, K.
Sciemtific Reports, DOI:10.1038/srep29261 www.nature.com/scientificreports
Telomere visualization in Tissue sections Using the Pyrrole-Imidazole Polyamide probes - Nokihara, K., Kasama, T., Tominaga, Y., Kitagawa, A., Hirata, A., Ohyama, T. and Yazawa, I., Amino Acids, online 08 June 2016, Doi:10.1007/s00726-016-2269-1, 2016 Nov; 48(11): 2491-2499.
High throughput sequencing of cyclic peptide immobilized on a gel-type single bead - Ohashi, Y., Ohnuma, R., Naganuma, T., Ogawa, T., Naude, R., Nokihara, K. and Muramoto, K. Food Science and Technology Research, 21 (5), 695-704, 2015.
Antioxidant Properties of Tripeptides Revealed by a Comparison of Six Different Assays - Nokihara, K., Tominaga, Kitagawa, A., Hirata, A. and Kasama, T. Peptide Science 2015, H. Hojo, T. Inazu, H. Katayama (eds.) The Japanese Peptide Society, pp 69-72, 2016.
High throughput amino acid analysis and sequence determination by a novel system without any derivatization using a novel column and mass spectrometer
2015年
- Nokihara,K., Hirata, A., Tominaga, Y., Kitagawa, A., Kasama, T. Peptide Science 2014, A. Ohtaka (ed.) The Japanese Peptide Society(2015), 51-54,Chemical Syntheses with QC-methods of Peptides Consisting of N-methyl pyrrole and N-methyl imidazole Residues and Elucidation of their Microheterogeneity
- Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Maeshima, K., Sasaki, A., Ide, S., Sugiyama, H. Peptide Science 2014, A. Ohtaka (ed.) The Japanese Peptide Society(2015), 73-74.
Synthesis and characterization of tandem hairpin polyamide for telomeres visualization - Tominaga, Y., Hirata, A., and Nokihara, K., Bioorg. Med. Chem. Lett. 25, 611–615, 2015.
Recognition of a monoclonal antibody against a small molecular weight antigen by monitoring the antigen–antibody reaction using fluorescence labeled structured peptides
2014年
- Hirata, A., Nokihara, K., Kawamoto, Y., Bando, T., Sasaki, A., Ide, S., Maeshima, K., Kasama, T., Sugiyama, H. J. Am. Chem. Soc. 136, 11546-11554, 2014.
Structural evaluation of tandem hairpin pyrrole-imidazole polyamides recognizing human telomeres - Hirata, A., Nokihara, K., Tetrahedron Lett. 55, 4091-4094, 2014.
Construction of peptide-vehicles, bioconjugates having modules of cancer cell surface capture and cell-penetrating peptide with anticancer agents, focusing on efficient drug delivery - Nokihara, K. Yajima, Y., Hirata, A., Prion, 8, 1-2, 2014.
Design and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP (mini review) - Nokihara, K. Tominaga, Y. Ueta G. Hirata, A., Peptide Science 2013, Y. Nishiuchi and T. Teshima (Eds.) The Japanese Peptide Society (2014) pp 389-392.
Recognition studies focusing on a novel bio-detection system using arrays consisting of fluorescent labeled structured peptides as capture molecules - Hirata, A., Miyajima, M., Tominaga, Y. Ueta G. Nokihara, K. Peptide Science 2013, Y. Nishiuchi and T. Teshima (Eds.) The Japanese Peptide Society (2014) pp 145-148.
Comparison of Recently Developed Polymer Supports for Assembly of Structured Polyamide in Solid-phase Syntheses
2013年
- Hirata, A., Miyajima, M., Nokihara, K., J. Liq. Chromatogr. Relat. Technol., 36, 2960- 2967, 2013.
Separation of peptides having structures and derivatives of mimosine, a nonproteinogenic amino acid, by a novel reverse- phase HPLC column packed with wide-pore silica - Nokihara, K., Yajima, S., Hirata, A., Sogon, T., Yasuhara, T., FEBS Lett., 587, 673-676, 2013. Characterization of peptides obtained from digests of bovine brain which accelerate structural conversions of the recombinant bovine prion protein
- Mihara, H., Usui, K., Tsutsumi, H. and Nokihara, K., Peptides, Peptides Across the Pacific, pp22-23, 2013, M. Label (Ed), Proceedings of the 23rd American Peptide Symposium
Designed Peptide Libraries for Cell Analyzing Microarrays - Nokihara, K., Pipkorn, R., Ohyama, T., Hirata, A., Miyajima, M., Ono, N., Peptide Science 2012: K. Sugimura (Ed) The Japanese Peptide Society, pp 167-170, 2013.
Improved Coupling Methods for the Difficult Amide-Bond Formation in Solid-Phase Assembly